NASA and the Department of Energy signed a Memorandum of Understanding on October 8, 2026, titled "Accelerating American Leadership in Space Nuclear Power and Propulsion." The agreement establishes end-to-end collaboration across research, fuel production, testing, launch integration, and operations for nuclear space systems. It was signed at the Golden Age Summit hosted by the Office of Science and Technology Policy at the Donald J. Trump Institute of Peace in Washington, effective November 1, 2026. The headline hardware commitments are concrete: Space Reactor-1 (SR-1) Freedom is targeted for a 2028 launch, which NASA describes as the transition of nuclear propulsion from laboratory research to operational deep-space application. Lunar Reactor-1 (LR-1) follows as a fission surface power system to sustain a future Moon base through the 14-day lunar night. President Trump's December 2025 Executive Order on Ensuring American Space Superiority directs NASA to develop a launch-ready lunar surface reactor by 2030. The near-term radioisotope portfolio is already in motion. The Dragonfly mission to Saturn's moon Titan, scheduled for 2028 launch, will carry a Multi-Mission Radioisotope Thermoelectric Generator and 24 Light Weight Radioisotope Heater Units to power its car-sized rotorcraft. NASA and DOE also plan to supply 24 similar heater units to ESA's Rosalind Franklin Mars rover for instrument temperature maintenance. What distinguishes this MOU from prior nuclear-space announcements is the specificity of named hardware on named timelines. SR-1 in 2028 and a launch-ready lunar reactor by 2030 are testable claims, not aspirational goals buried in a roadmap appendix. If SR-1 launches on schedule, it will represent the first operational fission system in deep space — a genuine capability inflection point that changes what missions are even possible. The structural question is whether the MOU creates binding programmatic commitments or merely aligns institutional intent. MOUs are frameworks, not appropriations. The fuel production pipeline — particularly for enriched uranium suitable for space reactors — has been a persistent bottleneck in U.S. space nuclear programs for decades. DOE's capacity to produce High-Assay Low-Enriched Uranium (HALEU) at scale remains the rate-limiting step that no amount of interagency goodwill can bypass. The generative case is strong in principle: nuclear power fundamentally changes the energy equation for planetary surface operations, enabling habitats, communications, rovers, resource extraction, and scientific instruments to operate through lunar night and Martian dust storms. This is not incremental — it is the difference between flags-and-footprints missions and sustained presence. The MOU also explicitly aims to build a domestic nuclear-space industrial base, which would create supplier ecosystems beyond the two agencies. The risk is the familiar pattern of ambitious nuclear-space timelines that slip. NASA's Kilopower project demonstrated a functional fission reactor in 2018, but translating ground demonstrations into flight-qualified, launch-certified hardware is where programs historically stall. The 2028 SR-1 date is 22 months away. Whether this MOU marks a genuine industrial mobilization or another chapter in the long history of nuclear-space announcements that outrun their funding will be visible within 18 months.