This is a Guardian letters page — six reader responses to recent reporting, loosely threaded by the theme of everyday friction. The lead letter, from Judith Furner of Eastbourne, cites US neuroscientist Ben Rein's research showing that in-person interactions produce dramatically higher levels of serotonin, oxytocin, and dopamine compared with online exchanges. Her takeaway is disarmingly practical: she's been encouraged to talk to strangers at bus stops. The neuroscience claim is real and directionally well-supported. Rein's social media science communication has popularized peer-reviewed findings on neurochemical responses to face-to-face versus screen-mediated contact. The core insight — that physical proximity triggers reward circuitry in ways that video calls and text do not — has implications for workplace policy, education design, and healthcare delivery that vastly exceed what a single letter can explore. Judith Pearson of Sheffield pivots to energy costs, flagging daily standing charges that consume half or more of her monthly energy bill. This is a structural extraction problem: standing charges are fixed costs that disproportionately burden low-usage households — often the elderly, single occupants, and the energy-conscious. The call for sliding-scale charges based on usage is a resilience intervention that would redistribute cost more fairly. The remaining letters are classic Guardian letters-page texture: a tautology sighting ('large drive-in car park'), complaints about being called 'young lady' or 'guys' in hospitality, the indignity of being called 'young man' at 91, and a dry note on the irony of air pollution impairing F1 racing in Singapore. What connects these fragments is a shared preoccupation with the gap between systems and the humans inside them. Energy billing structures that punish frugality. Hospitality scripts that flatten identity. Digital communication that starves the brain of chemicals it needs. Each letter identifies a small extraction — of dignity, money, or neurochemical wellbeing — embedded in daily life. The neuroscience letter is the one with policy legs. If in-person interaction is neurochemically superior by a significant margin, then every institution that defaults to digital-first — remote work mandates, telehealth expansion, online-only government services — is making a tradeoff with measurable biological costs. The standing-charge complaint is similarly structural: a pricing design that extracts from the least powerful users while remaining invisible to high-consumption households. None of these letters will change policy. But they map, collectively, the places where institutional design quietly degrades human experience — and where small redesigns (talk to someone at a bus stop, restructure standing charges, stop calling people 'guys') could generate outsized returns in wellbeing and trust.