Construction of the Deep Underground Neutrino Experiment begins Monday in the former Homestake gold mine near Lead, South Dakota. Engineers will spend roughly three years assembling four massive detectors inside caverns blasted from rock a mile below the surface, then another year filling them with 70,000 tonnes of liquid argon chilled to -200°C. The detectors stand up to five storeys high and are built from more than 4,000 tonnes of steel. The scale is industrial; the questions are existential. DUNE's core mission is to study neutrinos — chargeless, nearly massless particles that outnumber everything except photons. About a trillion pass through your body every second without interacting. They come in three varieties and oscillate between them in transit, a behaviour that remains unexplained by the Standard Model of physics. DUNE will fire an intense beam of neutrinos from Fermilab near Chicago through 800 miles of Earth's crust and mantle into the South Dakota detectors, watching for the rare occasions when a neutrino strikes an argon atom, producing a flicker of light and an electric charge pulse. The physics payoff is potentially enormous. DUNE aims to determine the mass ordering of the three neutrino types — which is lightest, which heaviest — a measurement that could reveal entirely new forces of nature. More ambitiously, it will search for subtle differences between neutrinos and antineutrinos, which could explain the matter-antimatter asymmetry: why the universe is made of stuff rather than nothing. Beyond the Fermilab beam, the detectors will also catch neutrinos from supernovae and other cosmic events, offering fresh data on stellar death and black hole formation. The site itself carries real scientific lineage. In the 1960s, Ray Davis built the first solar neutrino detector here — a 100,000-gallon tank of dry-cleaning fluid — work that eventually earned a Nobel Prize. The mine closed in 2001 and was converted into the Sanford Underground Research Facility (SURF), which already hosts the LUX-ZEPLIN (LZ) experiment, which last month reported a first potential detection of dark matter. DUNE is the next major step in transforming an extractive industrial site into a globally significant research facility. The UK is the largest international partner in the US-led experiment, contributing core detector components, computing infrastructure to reconstruct events, and the graphite target at Fermilab needed to generate the neutrino beam. The partnership leverages the UK's Science and Technology Facilities Council, and the project draws on Lead's skilled local workforce — a deliberate integration of community and science that Lead city administrator Robin Lucero frames as economic transformation: new people, new opportunities, new possibilities for local businesses and young people. The generative economics here are striking. A town built on gold extraction is now hosting an experiment that creates entirely new knowledge — the definition of expanding the pie rather than dividing it. The infrastructure is durable, multi-experiment, and designed for decades of operation. The risks are the standard ones for megascience: schedule slip, cost overruns, and the ever-present possibility that nature doesn't cooperate. Neutrino physics is slow, patient work. But the 2025 Nobel Prize for physics, awarded to Francis Halzen for detecting high-energy neutrinos using a cubic kilometre of Antarctic ice, signals that the field's payoff period is arriving. DUNE is a bet that fundamental physics still has surprises to deliver — and that a former mining town in South Dakota is the right place to find them. The conversion of Homestake from resource extraction to knowledge generation is itself a small model of the economic transition many communities need. Whether the physics delivers will take a decade to know. Whether the investment model works is already visible.